Psychedelic-Assisted Psychotherapy (PAP) emerges as a groundbreaking approach in psychiatric research, offering promising results in treating various mental health conditions. This paradigm shift focuses on using substances like ketamine, MDMA, and psilocybin within comprehensive psychotherapy programs. Demonstrating significant efficacy even in treatment-resistant cases, PAP challenges traditional psychiatric models, incorporating biopsychosocial factors and non-ordinary states of consciousness into treatment. This innovative method could reshape our understanding and approach to mental health therapy.