A study published in Nature Communications presents groundbreaking findings on ketamine's ability to reduce harmful drinking by pharmacologically altering drinking memories. The research demonstrates that ketamine, when administered immediately after the retrieval of maladaptive reward memories (MRMs), can effectively decrease the reinforcing effects of alcohol and long-term drinking levels in hazardous drinkers. This effect is attributed to ketamine's interference in the memory reconsolidation process, a novel approach that offers significant potential for treating alcohol and drug use disorders. The study highlights the predictive role of blood concentrations of ketamine and its metabolites during the critical reconsolidation window, paving the way for new therapeutic strategies in addiction treatment.