This innovative project explores the immediate and long-term effects of a single intravenous dose of ketamine in suicidal patients undergoing psychiatric consultation in a medical inpatient setting. The study extends beyond ketamine's rapid impact by integrating a computer-based training protocol designed to reinforce positive learning. This approach aims to enhance the treatment of suicidality, potentially making it more efficient and widely accessible by priming the brain for beneficial cognitive processes. This research could mark a significant advancement in the approach to managing acute suicidal thoughts and behaviors.